AKTIVITAS ANTIHIPERTENSI EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R.Forst. & G.Forst.) PADA MODEL HEWAN HIPERTENSI YANG DIINDUKSI PREDNISON DAN NaCl

Hypertension is a disease without symptoms that very dangerous (silent killer) because it often not realized. Conditions are controlled and occur continuously will cause factor related to cardiovascular disease. Empirically, matoa leaves commonly used as antihypertensive drugs. This study aims determine the activity of ethanolic extract diuretic antihypertensive. Diuretic testing was carried out for 6 hours with urine volume measurement every hour. Each test animal given warm water loading dose, using comparison (Furosemide 3.6 mg/KgBW) leaf ethanol group doses 150, 300, 500 mg/KgBW. Antihypertensive in preventive manner Prednisone 1.5 mg/KgBW NaCl 2%, (Hydrochlorothiazide 2.25 orally 14 days. The parameters were volume, systolic blood pressure diastolic pressure. data obtained analyzed One Way ANOVA Kruskall Wallis. results showed could increase output, decrease had comparable (p<0.05). A dose 150 mg/kgBW has most effective an